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Gene and Kidney Disease in People With Type 2 Diabetes.

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Goldberg AI, Dunlay MC, Sweet CS "Safety and tolerability of losartan potassium, and angiotensin II receptor antagonist, compared with hydrochlorothiazide, atenolol, felodipine ER, and angiotensin-converting enzyme inhibitors for the treatment of systemic hypertension.

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ARBs prevent the hypertensive effects of angiotensin II by selective blockade of the angiotensin II type 1 (AT 1) receptor.

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Patients receiving the combination of Losartan and lisinopril did not obtain any additional benefit compared to monotherapy for the combined endpoint of decline in GFR, end stage renal disease, or death, but experienced an increased incidence of hyperkalemia and acute kidney injury compared with the monotherapy group.

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Losartan and certain other medicines may interact with each other.

If you do not take your losartan-hydrochlorothiazide as scheduled, take your next dose as soon as you remember.

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Renal function should be monitored closely for the first few weeks of therapy.

Concomitant hydrochlorothiazide therapy in hypertensive patients is associated with reduced cardiovascular morbidity and mortality independent of blood pressure and electrocardiographic left ventricular hypertrophy: the LIFE study.

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In this population, losartan potassium reduces the rate of progression of nephropathy as measured by the occurrence of doubling of serum creatinine or end stage renal disease (need for dialysis or renal transplantation) (see CLINICAL PHARMACOLOGY, and Clinical Effects).

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Subjects who do not metabolize losartan to active metabolite have been shown to have a specific, rare defect in cytochrome P450 2C9.

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On the other hand, an analysis of combined data from the Framingham Heart Study and the National Health and Nutrition Examination Survey (NHANES) II has also shown that a small reduction in DBP, of just 2-mmHg, would produce a substantial reduction in the incidence of primary cardiovascular events within the community.

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