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Goldberg AI, Dunlay MC, Sweet CS "Safety and tolerability of losartan potassium, and angiotensin II receptor antagonist, compared with hydrochlorothiazide, atenolol, felodipine ER, and angiotensin-converting enzyme inhibitors for the treatment of systemic hypertension.
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Renal function should be monitored closely for the first few weeks of therapy.
Concomitant hydrochlorothiazide therapy in hypertensive patients is associated with reduced cardiovascular morbidity and mortality independent of blood pressure and electrocardiographic left ventricular hypertrophy: the LIFE study.
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Subjects who do not metabolize losartan to active metabolite have been shown to have a specific, rare defect in cytochrome P450 2C9.
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On the other hand, an analysis of combined data from the Framingham Heart Study and the National Health and Nutrition Examination Survey (NHANES) II has also shown that a small reduction in DBP, of just 2-mmHg, would produce a substantial reduction in the incidence of primary cardiovascular events within the community.
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